RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes
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RKIP Suppresses Breast Cancer Metastasis to the Bone by Regulating Stroma-Associated Genes
In the past decade cancer research has recognized the importance of tumorstroma interactions for the progression of primary tumors to an aggressive and invasive phenotype and for colonization of new organs in the context of metastasis. The dialogue between tumor cells and the surrounding stroma is a complex and dynamic phenomenon, as many cell types and soluble factors are involved. While the f...
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Long noncoding RNA NBAT1 (neuroblastoma associated transcript 1) regulates cell proliferation and invasion by interacting with PRC2 (polycomb repressive complex 2) member EZH2 (enhancer of zeste 2). Decreased expression of NBAT1 is associated with poor clinical outcome in neuroblastomas. However, the roles of NBAT1 in other cancers remain unknown. Here, we report that NBAT1 is down-regulated in...
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ژورنال
عنوان ژورنال: International Journal of Breast Cancer
سال: 2012
ISSN: 2090-3170,2090-3189
DOI: 10.1155/2012/124704